- Title
- AadT, a New Weapon in Acinetobacter's Fight Against Antibiotics
- Creator
- Naidu, Varsha; Shah, Bhumika; Maher, Claire; Paulsen, Ian T.; Hassan, Karl A.
- Relation
- ARC.FT180100123 http://purl.org/au-research/grants/arc/FT180100123
- Relation
- Microbiology Vol. 169, Issue 5, no. 001341
- Publisher Link
- http://dx.doi.org/10.1099/mic.0.001341
- Publisher
- The Microbiology Society
- Resource Type
- journal article
- Date
- 2023
- Description
- Genes encoding a novel multidrug efflux pump, AadT, from the Drug:H + antiporter 2 family, were discovered in Acinetobacter multidrug resistance plasmids. Here, we profiled the antimicrobial resistance potential, and examined the distribution of these genes. aadT homologs were found in many Acinetobacter and other Gram-negative species and were typically adjacent to novel variants of adeAB(C), which encodes a major tripartite efflux pump in Acinetobacter. The AadT pump decreased bacterial susceptibility to at least eight diverse antimicrobials, including antibiotics (erythromycin and tetracycline), biocides (chlorhexidine), and dyes (ethidium bromide and DAPI) and was able to mediate ethidium transport. These results show that AadT is a multidrug efflux pump in the Acinetobacter resistance arsenal and may cooperate with variants of AdeAB(C).
- Subject
- Acinetobacter baumannii; Acientobacter plasmids; antimicrobial resistance; efflux pumps; Facilitator Superfamily (MFS); RND efflux
- Identifier
- http://hdl.handle.net/1959.13/1480286
- Identifier
- uon:50476
- Identifier
- ISSN:1350-0872
- Rights
- © 2023 The Authors This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
- Language
- eng
- Full Text
- Reviewed
- Hits: 1108
- Visitors: 1160
- Downloads: 58
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 1 MB | Adobe Acrobat PDF | View Details Download |